Non Invasive Blood Glucose Monitor

Top 5 companies developing non-invasive glucose monitors in 2023

The successful development of a non-invasive glucose monitor that can accurately measure blood sugar levels for diabetics without the need to prick the skin has been in the works for decades.

Why wouldn’t diabetes patients flock to a device that can take blood sugar levels through saliva, sweat, or a wristband that uses radiofrequency technology?

Even in the midst of the COVID-19 pandemic, many companies have been pushing forward CGM (noninvasive continuous glucose monitoring) space.

However, to date, it has been hope versus hype, as attempts to develop accurate non-invasive glucose monitors have failed. Yet, experts still have hope for the potential for non-invasive devices to soon become a reality in the next 5 years.

How does a non-invasive glucose monitor work?

There are systems being developed for home use as well as hospital and in-clinic use. Home systems are typically wearables whereas hospital systems will be tabletop or non-wearable systems.

Analysts categorize non-invasive glucose monitors by the type of technology used – mainly, various forms of spectroscopy, which helps identify chemicals according to the interaction of electromagnetic radiation and molecules.

Can I check my blood without pricking my finger?

Spectroscopy uses lasers and it does not prick the skin. Researchers have been studying this technique for decades with scientists from universities such as MIT finding that it can be used to produce accurate data on blood sugar levels. Although many barriers still exist, scientists predict that non-invasive glucose monitoring is poised for success in the near future.

Non-invasive glucose monitoring devices can be classified into three main categories:

NIO-GM (non-invasive optical glucose monitoring: Is designed to pass a type of radiation through vascular regions of the body.
NIFS-GM (non-invasive fluid sampling): These devices analyze fluid samples (saliva, urine, sweat, tears, etc.) that are collected non-invasively.
MI-GM (minimally invasive devices): Involves inserting a sensor just underneath the skin (in the subcutaneous layer), such as CGM devices that exist today.

Who is developing non-invasive continuous glucose monitoring devices?

Here are some tech companies currently making progress in the non-invasive CGM space:

1. Scanbo

Scanbo Non invasive glucose monitor — ‘Scanbo’ Non-invasive glucose monitor

At the CES (Consumer Electronics Show) In January 2022, Scanbo, an AI (Artificial Intelligence) company based in British Columbia gave a glance at their technology that uses a 60-second non-invasive finger measurement rather than the traditional finger prick.

Scanbo has created a prototype that uses a combination of a Photoplethysmogram (PPG) and a 3-lead ECG to measure blood volume. The device requires users to place their fingers on a white sensor and the device uses a combination of algorithms to provide insight into blood glucose values.

2. GWave

GWave, from Israel-based Hagar Technology, is a non-invasive glucose monitoring device that features a sensor placed inside a lightweight bracelet that detects glucose levels using radio frequencies.

The bracelet connects to a mobile app that displays readings and allows users to share data with their doctors. Hagar Technology received FDA (Food and Drug Administration) fast-track title in 2021 after receiving funding from a series of investors.

The company has reported that clinical trials for the GWave are in progress.

3. SugarBEAT

Nemaura Medical, a company based in the UK has developed SugarBEAT, a non-invasive glucose monitor that has already been approved for use in Europe. It is a small patch that attaches to the skin for up to 24 hours before requiring replacement. The peel-and-patch rectangular transmitter sends readings via Bluetooth to a companion mobile app every 5 minutes.

The device passes a non-perceptible electric current through the skin, which draws small amounts of glucose molecules into the patch attached to the skin. Selected molecules are drawn from the interstitial fluid just below the skin’s top layer.

Although Nemaura Medical had originally submitted SugarBeat to the FDA in 2019, the company was requested to resubmit it with additional data. Meanwhile, the company is launching proBeat in the US, an unregulated CGM version designed for people with type 2 diabetes.

4. Know Labs

KnowU and UBand Non invasive glucose monitoring — KnowU and UBand Bio-RFID non-invasive blood glucose monitors

Know Labs, a company based in Seattle, Washington is developing two non-invasive glucose monitoring devices that use Bio-RFIS (Body-Radio Frequency Identification) technology which measures molecular signatures in the blood using radio waves.

The company is developing a finger-scanning device as well as a wristband-style device that eliminates the hassle of having to prick the skin to get blood glucose readings.

UBand

UBand is a wristband-style device with an in-built biosensor that continuously monitors sugar levels. The device will send the readings to a smartphone app where users can view and analyze readings. The device will have a battery life of up to 7 days and is aimed at diabetes patients who are interested in continuous glucose monitoring.

KnowU

Just like traditional gingerstick glucose meters, Know you are small enough to fit in your purse or pocket. However, unlike traditional glucose monitors, it does not require test strips.

You simply need to scan the device over your palm to get readings that will be displayed on the device itself or transmitted wirelessly to a mobile phone app. This device is mainly aimed at people with diabetes who want a small, portable device that can be used to monitor glucose levels without the traditional finger pricks.

Read more on diabetic watches HERE!

5. DiaMonTech

DiaMonTech is a Germany-based company that has created a system that employs molecular spectroscopy to detect blood sugar molecules right through the skin. The company is currently working on 3 versions:

The D-Pocket, is a hand-held device that requires users to press their finger on the device to get a reading. The device is anticipated for 2023 or later
A D-sensor that can be embedded in fitness bands or watches, is not expected before 2024.
A shoebox-size system that is designed for hospital settings, and is currently available for use.

Other companies currently working on non-invasive glucose monitors include NovioSense, LifePlus, Afon Technology, Apple, and Samsung.

Read more on Diabetes Patches for Continuous blood glucose monitoring HERE!

The bottom line

These are just a few of the numerous biotechnology companies and startups seeking to develop non-invasive glucose monitors. Over the last several decades, we have advanced from measuring glucose levels in urine to fingersticks and blood testing to CGM.

Check out the article on the Dexcom CGM G6!

Although much has changed, the need for body fluids to take blood glucose measurements has remained constant. Fortunately, technology is rapidly improving, and while we may not yet have the most reliable non-invasive glucose monitors on the market, the puzzle could be completed in the next couple of years.

Exploring the Different Types of Blood Glucose Testers

Post updated: 12.04.2023

Blood glucose testers, also known as glucometers, are devices used to measure the amount of glucose present in a person’s blood. These devices have become increasingly important for those of us with diabetes, a condition characterized by high blood glucose levels.

There are a few different types of blood glucose testers available, each with its own unique features and benefits. In this article, we will explore the various types of blood glucose testers and their advantages and disadvantages

1. Fingerstick Glucose Testers

Fingerstick glucose testers, also known as blood glucose meters, are small devices that people with diabetes can use to check their blood sugar levels. They are the most commonly used type of blood glucose testers.

They require a small drop of blood, typically obtained by pricking the fingertip with a lancet, which is then placed on a test strip. The test strip is then inserted into the meter, which analyzes the blood glucose level. There are several advantages and disadvantages to using these devices.

Advantages:

Accuracy: Fingerstick glucose testers provide accurate and reliable results, which are important for managing diabetes effectively.
Portability: These devices are small and portable, which means they can be carried easily anywhere and used anytime.
Ease of use: Most fingerstick glucose testers are user-friendly and require only a small blood sample, which can be obtained through a tiny prick on the finger.
Immediate results: The results are available almost instantly, allowing people with diabetes to make immediate adjustments to their treatment plan.

Cost-effective: These testers are widely available and are relatively inexpensive.

Disadvantages:

Pain: Some people find finger pricks to be painful or uncomfortable, and may be reluctant to use these devices as often as recommended.
Inconvenience: Fingerstick glucose testing requires carrying around the device and test strips, and taking the time to perform the test several times a day.
Inaccuracy: Results can be affected by various factors, such as the quality of the test strips, the cleanliness of the device, and the technique used to obtain the blood sample.
Risk of infection: Repeated finger pricks can increase the risk of infection, especially if proper hygiene is not observed.
Limited information: Fingerstick glucose testers only provide information about blood sugar levels at the time of the test and do not provide insights into trends or patterns in blood sugar levels over time.

Overall, fingerstick glucose testers are a useful tool for people with diabetes to monitor their blood sugar levels, but they have their limitations and drawbacks that need to be considered.

2. Continuous Glucose Monitoring Systems (CGMs)

CGMs are a relatively new type of blood glucose tester that allows for continuous monitoring of blood glucose levels. They consist of a small sensor that is inserted under the skin, typically on the abdomen, which measures glucose levels in the interstitial fluid. The sensor is connected to a transmitter, which sends the data to a receiver or smartphone app.

Advantages:

CGMs provide continuous monitoring of blood glucose levels, allowing individuals to see how their levels change throughout the day and how their insulin dosage or dietary intake affects their levels.
These systems can alert individuals when their blood glucose levels are too high or too low, allowing them to take corrective action before a serious complication occurs.
CGMs can be particularly useful for individuals who have difficulty detecting the symptoms of hypoglycemia (low blood glucose levels) or who experience frequent hypoglycemia.

Disadvantages:

CGMs can be expensive, particularly if not covered by insurance.
The sensors must be replaced every few days, which can be a hassle for some individuals.
The sensors can sometimes be inaccurate, particularly if they are not placed correctly or if there is a problem with the transmitter or receiver.

3. Noninvasive Glucose Testers

Noninvasive glucose testers are a newer type of blood glucose meter that does not require a blood sample. Instead, they use a variety of techniques, including light, sound waves, and electrical currents, to measure glucose levels through the skin.

Advantages:

These testers are painless and do not require a blood sample, making them ideal for individuals who are sensitive to needles or who have a fear of blood.
They can be used more frequently than fingerstick glucose testers, as they do not require a break in the skin.
Noninvasive glucose testers can be particularly useful for children, who may be afraid of needles.

Disadvantages:

Noninvasive glucose testers are still in the early stages of development and are not yet widely available.
They can be expensive and may not be covered by insurance.
The accuracy of these testers can be variable, and they may not be as reliable as fingerstick glucose testers or CGMs.

4. Implantable Glucose Sensors

Implantable glucose sensors are a type of Continuous Glucose Monitoring System (CGM) that are placed under the skin to continuously measure glucose levels in the interstitial fluid. They are a relatively new type of blood glucose tester that has the potential to revolutionize the way diabetes is managed.

These implantable glucose sensors work by using a tiny electrode that is inserted under the skin. The electrode measures the glucose levels in the interstitial fluid, which is the fluid that surrounds the cells in the body. The glucose levels are then transmitted to a receiver or smartphone app.

The sensors are typically inserted into the arm or abdomen using a needle or small incision. The procedure is usually performed in a doctor’s office or hospital and can be done under local anesthesia. Once the sensor is inserted, it is secured in place using an adhesive patch.

Advantages:

Continuous monitoring: Implantable glucose sensors allow for continuous glucose monitoring, which can be especially helpful for people with diabetes. It eliminates the need for fingerstick testing, which can be painful and inconvenient.
Accuracy: Implantable glucose sensors are generally more accurate than traditional glucose meters. They measure glucose levels directly in the interstitial fluid, which is more closely related to blood glucose levels than capillary blood.
Alerts: Some implantable glucose sensors can send alerts when glucose levels become too high or too low, helping individuals manage their condition proactively.
Improved glucose management: Continuous glucose monitoring with implantable glucose sensors can help individuals identify patterns in their glucose levels and make adjustments to their treatment plans to achieve better glucose control.

Disadvantages:

Invasive procedure: Implantable glucose sensors require a surgical procedure to implant the device, which carries a risk of infection or other complications.
Cost: Implantable glucose sensors can be expensive, and not all insurance plans cover them.
Calibration: Implantable glucose sensors need to be calibrated regularly to ensure accurate readings, which can be time-consuming and may require multiple fingerstick tests.
Battery life: The battery life of implantable glucose sensors is limited, and the device needs to be replaced periodically.

It is essential to discuss the advantages and disadvantages of implantable glucose sensors with a healthcare provider to determine if they are the right choice for an individual’s particular needs and circumstances.

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